Functional Lab Test

Liver Function Test (Hepatic Detox)

Our liver is one of the largest organs in your body. It helps remove waste products and processes various nutrients and medicines. Detoxification is an ongoing, essential process that your body does in order to survive. It happens 24/7, 365 days of the year.

The human body attempts to eliminate xenobiotics (foreign organic chemicals) through a concerted effort of enzymatic “functionalization” (phase I) and conjugation (phase II). Functionalization leads to chemical modification of the xenobiotic by the cytochrome P-450 or the “mixed function oxidase” enzyme systems. Once functionalized, the altered xenobiotic can then be conjugated and excreted out. Urinary D-glucaric acid, a hepatic byproduct of enzymatic response to chemical toxins (phase I), is a reliable indicator of of chemical exposure to over 200 chemicals. Mercapturic acids are direct, excretory end products of the functionalized xenobiotics that have been conjugated with glutathione prior to excretion. Together, assessment of these two analytes provides valuable information about exposure to xenobiotics, liver disease and the ability of the liver to eliminate toxins. This non-invasive test requires a single, first morning void (FMV) urine collection.

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