Functional Lab Test

Osteoarthritis / Cartilage Damage Test

Most would agree that they would prefer to know it earlier. Arthritis can be difficult to diagnose in the early stages; it is usually diagnosed by physical examination and imaging studies. However, there is a lack of accuracy in assessing early stages of arthritis in physical examination, and imaging studies often only detect arthritic changes after significant damage has occurred.

A recent study demonstrated that when CTX-II levels were compared in young athletes, they were highest in runners, moderate in rowers and lowest in swimmers. Increases in CTX-II have been shown to correlate with joint pain, and levels usually increase before radiological changes become obvious. Therefore, the detection of osteoarthritis during early stages, with accurate and reliable biomarkers such as CTX-II, may help preserve joint function, decrease pain and disability, and prevent further deterioration of disease progression.

Detection of CTX-II in serum and urine to diagnose osteoarthritis:
https://www.ncbi.nlm.nih.gov/pubmed/25172026

Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754328/

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